HPE has announced an enhancement to its NVIDIA AI computing portfolio, introducing new Blackwell-powered servers aimed at bolstering enterprise capabilities for managing the entire AI lifecycle. This upgrade focuses on improving integration with NVIDIA AI Enterprise while also supporting the latest AI models and Blueprints.
At the heart of this update are the HPE ProLiant Compute servers, which feature NVIDIA RTX PRO 6000 Blackwell Server Edition GPUs. The release showcases two specific configurations: the HPE ProLiant DL385 Gen11 server, which can accommodate up to two RTX PRO 6000 GPUs within a 2U form factor with air cooling, catering to the growing demands for AI processing. Meanwhile, the HPE ProLiant Compute DL380a Gen12 server is set to launch in September and will support up to eight RTX PRO 6000 GPUs housed in a 4U chassis for more intensive workloads.
These server systems are tailored for versatile enterprise applications, including generative AI, robotics, industrial AI, 3D modeling, and more, including visual computing tasks essential for quality control and autonomous vehicle operations. HPE’s ProLiant Gen12 lineup also introduces enhanced security features such as iLO 7 Silicon Root of Trust and quantum-resistant firmware signing. The management of these systems can be streamlined through HPE Compute Ops Management, a cloud-native platform that claims to decrease administrative tasks by up to 75% and minimize downtime significantly.
This hardware launch coincides with HPE’s introduction of the next generation of HPE Private Cloud AI, developed in collaboration with NVIDIA. The updated platform will offer support for NVIDIA RTX PRO 6000 GPUs, scalable GPU generation, secure management environments, and multi-tenancy for enterprises, expected to be available later this year.
Moreover, HPE’s Private Cloud AI will integrate compatibility with NVIDIA’s latest reasoning models and AI tools, facilitating the build of AI agents capable of leveraging extensive video datasets for analytics. The collaborative efforts with NVIDIA assure that enterprises can rapidly deploy NVIDIA NIM microservices and the newest AI Blueprints through HPE AI Essentials.
By strengthening the integration with NVIDIA’s technology stack, HPE aims to empower enterprises in addressing the increasing demands for AI inferencing while maintaining control over sensitive data. HPE executives framed this announcement as a significant progress toward allowing enterprises to confidently adopt AI across a diverse range of workloads, emphasizing that the partnership with NVIDIA continues to drive innovation in meeting the unique requirements of enterprise-level operations.
The HPE ProLiant DL385 Gen11 and ProLiant Compute DL380a Gen12 servers featuring NVIDIA RTX PRO 6000 Blackwell GPUs are already available for order, with shipments slated to start on September 2, 2025. Additionally, support for the latest AI models and the new HPE Private Cloud AI will be provided in the latter half of 2025.
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